ABSTRACT
Intro: Patients receiving B-cell depleting or inhibiting therapies (BCDT), such as anti-CD20 monoclonal antibodies (CD20-MAB), are at risk for severe COVID-19. BCDT decreases production of neutralizing antibodies, causing delayed viral clearance and prolonged viral shedding. Passive antibody therapy (PAT), including COVID-19 convalescent plasma (CCP) and monoclonal antibodies (MAB), is hypothesized to be an effective Findings: * At the time of treatment, all patients (19/19) receiving CCP were hospitalized compared with10/53 patients treated with MAB. 2/10(20%) hospitalized patients treated with MAB died, compared with 3/19(15%) treated with CCP. **5/43 patients treated outpatient with MAB were hospitalized for COVID following CCP/MAB treatment with no COVID related deaths. Conclusion(s): Our data suggest that patients with COVID-19 who received BCDT within the last year may have improved outcomes after treatment with MAB or CCP. Elderly patients with >3 comorbidities and underlying hematological malignancy who contracted COVID-19 within 30 days of last BCDT had increased morbidity and mortality. To improve clinical outcomes, passive antibody therapy should be administered prior to the development of severe disease requiring hospitalization. Further prospective studies and comparisons to COVID-19 patients that did not receive MAB or CCP are needed to help confirm this association.Copyright © 2023
ABSTRACT
The COVID-19 pandemic has resulted in unprecedented changes in the trucking industry. 70% of all freight tonnage goes on trucks, including essential items such as food, medical supplies, and cleaning products. COVID-19 caused surges in demand for many of these products, impacting the trucking companies. Medical supplies, cleaning supplies, food, and even the COVID-19 vaccine itself rely on the trucking industry to be distributed across the nation, creating a new, increased demand for goods. The increase in demand caused a surge of trucks on the road, which is a good sign for the business, but at a cost to the drivers during these times. Closures due to the pandemic created problems for long-haul truckers who are on the road and need a place to rest, get gas, or buy food. Besides, truckers are now expected to work longer hours and make longer trips to meet the new demand. The limitations that the pandemic has created on the trucking industry have also affected the overall revenue. Trucking companies are reluctant to send trucks to highly impacted areas, even if those areas contribute most to the increased demand. This paper will explore the different ways that COVID-19 affected the trucking industry, how they responded, and how their response continues to affect the industry. © IEOM Society International.